Science

T-MATE™ Pipeline

Focusing on generating innovative biological respondents with a unique mode of action coupled with conditionally activated characteristics, we handle high-value disease targets with huge upside potential, which are otherwise intractable for traditional targeting approaches.

T-MATEs: Tumor Microenvironment Activated Therapeutics

*Undisclosed Targets

Platform Technology

Amberstone has developed a microfluidics-based discovery engine (AmberFlow™) that integrates patent-protected systems and methods with our deep understanding of single cell biology. By utilizing single cell functional analysis in a tunable microenvironment, the AmberFlow™ platform enables efficient isolation of rare high-value therapeutic candidates.

Unique Advantages of AmberFlow™

  • Agnostic: Not limited by molecular format, cell sources or target
  • Ultra-high throughput, tunable single-cell functional assays under disease relevant conditions
  • In-depth interrogation of individual candidates with high-speed and high-content information

Paving the Way for Safer Therapeutics

Microenvironment Selective

Activated by tumor specific glycolytic metabolism

Agnostic
Biologics

Antibodies, immunocytokines & fusion proteins

Wide Therapeutic
Window

Significantly reduced off-tumor and off-target toxicity

Flexible Targeting Approaches

Mono- or multi-specific targeting of immune and/or tumor cells

Publications

Functional TCR T cell screening using single-cell droplet microfluidics. Aude I. Segaliny, Guideng Li, Lingshun Kong, Ci Ren, Xiaoming Chen, Jessica K. Wang, David Baltimore, Guikai Wu and Weian Zhao. Lab Chip, 2018, 18:3733-3749.

A high throughput bispecific antibody discovery pipeline. Aude I. Segaliny, Jayapriya Jayaraman, Xiaoming Chen, Jonathan Chong, Ryan Luxon, Audrey Fung, Qiwei Fu, Xianzhi Jiang, Rodrigo Rivera, Xiaoya Ma, Ci Ren, Jan Zimak, Per Niklas Hedde, Yonglei Shang, George Wu, Weian Zhao. BioRxiv 2021.09.07.459213

Collaborate with Us

At Amberstone, we are constantly striving to bring our technologies and platform into more realms of therapeutic research. We welcome the opportunity for new partnerships and alliances that can further our goals in discovering next-generation therapeutic biologics.

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Phone: +1-(949) 331-3934

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