Associate Scientist/Scientist – Assay Development

Laguna Hills, CA, USA

About the Role

We are seeking a highly motivated, creative, and experienced Assay Development biologist to join our Assay Biology team at Amberstone Biosciences Inc. The candidate will play a key role in the evaluation of leads for immune modulation and will be responsible for executing and optimizing a wide-range of biochemical and cell-based assays for the evaluation and profiling of hits from our screens and for lead optimization. Hands-on experience and in-depth knowledge of primary immune cells handling and standard immunoassays (B/T/NK cells isolation and culture, flow cytometry, ELISA) are required. The position will report to the Director of Assay Biology.

Requirements

  • MS or PhD in Immunology, Cancer biology, Molecular & Cellular Biology, or a related field with at least 3 years of wet-bench research experiences; Industry experience is a plus;
  • Highly experienced and knowledgeable in cell isolation and culture (primary B, T, NK cells and monocytes/macrophages, cell lines, single cell cloning, lentiviral transduction) and direct experiences with general cellular biology techniques (flow cytometry, cell culture, ELISA, western blot, etc.);
  • Direct experience with immunoassays is preferred (proliferation, profiling, etc.)
  • Direct experiences in mouse handling (housing, monitoring, weighting, measuring temperature, measuring tumor size using a caliper among others); proven expertise in performing blood collection (both from tail-vein and retro-orbital), as well as i.p., s.c., and i.v. (tail-vein and retro-orbital) injections. Experience in tumor inoculation and IACUC protocols writing is a plus.
  • Experience with signaling pathways/transcription factors and reporter assays is a plus;
  • Experiences with droplet microfluidics-based assays would be an asset; Experience with molecular biology, biochemical assays and molecular biology techniques is a plus;
  • Excellent organizational, interpersonal and communication skills and can thrive in highly collaborative research environment;
  • Demonstrated technical proficiency, ability to troubleshoot to solve problems and to deliver high quality data; Ability to work well under pressure to provide results in a short timeframe;
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  • Highly motivated, willing to work in a fast-pace team environment with a variable/flexible schedule. Caring mindset, excellent leadership, clear communication, and excellent problem-solving skills. Good time management, working efficiently within a team, fast learner, easily adjusting to new priorities.
  • Key Responsibilities

  • Independently design and optimize biochemical and cell-based in vitro assays
  • Evaluate new hits with in vitro assays (tumor killing, cytokine measurement, immune cell proliferation and profiling, etc.)
  • Perform animal work (mainly mice studies) to characterize lead molecules in vivo
  • Establish SOPs to streamline validated assays
  • Analyze data and communicate results in project team meetings
  • Work closely with scientists across the teams in biochemistry, platform, molecular biology and assay biology to efficiently move projects forward
  • Salary/Benefits

    Salary range is commensurate with skills and experience, plus competitive fringe benefits and generous stock options.

    We offer 401(k) retirement plan, health care and dependent care FSA.

    About the Company

    Amberstone Biosciences is a preclinical biotherapeutic company located in Orange County, California. We discover transformative immunotherapeutic antibodies including bispecific and multispecific molecules that uniquely address tumor microenvironment in part through developing highly innovative single-cell functional discovery platform technology. We believe that innovation is the foundation of our successes and our employees are the most valuable assets. We welcome people with adventurous spirits to join us, grow with us and prosper with us.